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Multiple malignancy

MedGen UID:
577404
•Concept ID:
C0346429
•
Neoplastic Process
Synonyms: CA - Multiple cancer; Multiple cancer
SNOMED CT: Multiple cancer (363500001); CA - Multiple cancer (363500001); Multiple malignancy (363500001)

Professional guidelines

PubMed

Differences in the management of thyroid nodules in children and adolescents as compared to adults.
Goldfarb M, Dinauer C
Curr Opin Endocrinol Diabetes Obes 2022 Oct 1;29(5):466-473. Epub 2022 Jul 2 doi: 10.1097/MED.0000000000000754. PMID: 35777975
Risk assessment for thrombosis in cancer.
Gomes M, Khorana AA
Semin Thromb Hemost 2014 Apr;40(3):319-24. Epub 2014 Mar 5 doi: 10.1055/s-0034-1370770. PMID: 24599438
Interferon-alpha in the treatment of multiple myeloma.
Khoo TL, Vangsted AJ, Joshua D, Gibson J
Curr Drug Targets 2011 Mar 1;12(3):437-46. doi: 10.2174/138945011794815329. PMID: 21143148

Recent clinical studies

Etiology

Spinal Metastasis in Multiple Primary Malignancies Involving Lung Cancer: Clinical Characteristics and Survival.
Truong VT, Al-Shakfa F, Newman N, Roberge D, Masucci GL, Tran TPY, Boubez G, Shedid D, Yuh SJ, Wang Z
World Neurosurg 2022 Nov;167:e726-e731. Epub 2022 Aug 24 doi: 10.1016/j.wneu.2022.08.084. PMID: 36030008
Prognostic Value of Soluble Programmed Cell Death Ligand-1 (sPD-L1) in Various Cancers: A Meta-analysis.
Li X, Zheng Y, Yue F
Target Oncol 2021 Jan;16(1):13-26. doi: 10.1007/s11523-020-00763-5. PMID: 33222017
Newly developed primary malignancies in long-term survivors who underwent curative esophagectomy for squamous cell carcinoma of the esophagus.
Shimizu D, Koike M, Kanda M, Sonohara F, Hattori N, Hayashi M, Tanaka C, Yamada S, Kodera Y
Surg Today 2021 Jan;51(1):153-158. Epub 2020 Jul 7 doi: 10.1007/s00595-020-02072-w. PMID: 32638131
Demographical Profile and Spectrum of Multiple Malignancies in Children and Adults with Neurocutaneous Disorders.
Marjanska A, Jatczak-Gaca A, Wojtkiewicz A, Wysocki M, Styczynski J
Anticancer Res 2018 Sep;38(9):5453-5457. doi: 10.21873/anticanres.12877. PMID: 30194202
Lung Cancer and Multiple Neoplasms: A Retrospective Analysis.
Romaszko A, Świetlik E, Doboszyńska A, Szpruch P, Luks J
Adv Exp Med Biol 2016;911:53-8. doi: 10.1007/5584_2016_224. PMID: 26987325

Diagnosis

Spinal Metastasis in Multiple Primary Malignancies Involving Lung Cancer: Clinical Characteristics and Survival.
Truong VT, Al-Shakfa F, Newman N, Roberge D, Masucci GL, Tran TPY, Boubez G, Shedid D, Yuh SJ, Wang Z
World Neurosurg 2022 Nov;167:e726-e731. Epub 2022 Aug 24 doi: 10.1016/j.wneu.2022.08.084. PMID: 36030008
CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors.
Chen Y, Huang Y, Gao X, Li Y, Lin J, Chen L, Chang L, Chen G, Guan Y, Pan LK, Xia X, Guo Z, Pan J, Xu Y, Yi X, Chen C
Front Immunol 2020;11:1620. Epub 2020 Aug 10 doi: 10.3389/fimmu.2020.01620. PMID: 32903763Free PMC Article
Demographical Profile and Spectrum of Multiple Malignancies in Children and Adults with Neurocutaneous Disorders.
Marjanska A, Jatczak-Gaca A, Wojtkiewicz A, Wysocki M, Styczynski J
Anticancer Res 2018 Sep;38(9):5453-5457. doi: 10.21873/anticanres.12877. PMID: 30194202
Lung Cancer and Multiple Neoplasms: A Retrospective Analysis.
Romaszko A, Świetlik E, Doboszyńska A, Szpruch P, Luks J
Adv Exp Med Biol 2016;911:53-8. doi: 10.1007/5584_2016_224. PMID: 26987325
Detection of lymph node metastases by gadolinium-enhanced magnetic resonance imaging: systematic review and meta-analysis.
Klerkx WM, Bax L, Veldhuis WB, Heintz AP, Mali WP, Peeters PH, Moons KG
J Natl Cancer Inst 2010 Feb 24;102(4):244-53. Epub 2010 Feb 1 doi: 10.1093/jnci/djp514. PMID: 20124189

Therapy

CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors.
Chen Y, Huang Y, Gao X, Li Y, Lin J, Chen L, Chang L, Chen G, Guan Y, Pan LK, Xia X, Guo Z, Pan J, Xu Y, Yi X, Chen C
Front Immunol 2020;11:1620. Epub 2020 Aug 10 doi: 10.3389/fimmu.2020.01620. PMID: 32903763Free PMC Article
MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM).
Fan X, Zhou S, Zheng M, Deng X, Yi Y, Huang T
Biomed Pharmacother 2017 Apr;88:507-514. Epub 2017 Jan 23 doi: 10.1016/j.biopha.2017.01.058. PMID: 28126676

Prognosis

Spinal Metastasis in Multiple Primary Malignancies Involving Lung Cancer: Clinical Characteristics and Survival.
Truong VT, Al-Shakfa F, Newman N, Roberge D, Masucci GL, Tran TPY, Boubez G, Shedid D, Yuh SJ, Wang Z
World Neurosurg 2022 Nov;167:e726-e731. Epub 2022 Aug 24 doi: 10.1016/j.wneu.2022.08.084. PMID: 36030008
Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung adenocarcinoma.
Jiang J, Lu Y, Zhang F, Pan T, Zhang Z, Wan Y, Ren X, Zhang R
BMC Cancer 2022 Jun 8;22(1):632. doi: 10.1186/s12885-022-09696-w. PMID: 35676688Free PMC Article
Prognostic Value of Soluble Programmed Cell Death Ligand-1 (sPD-L1) in Various Cancers: A Meta-analysis.
Li X, Zheng Y, Yue F
Target Oncol 2021 Jan;16(1):13-26. doi: 10.1007/s11523-020-00763-5. PMID: 33222017
Demographical Profile and Spectrum of Multiple Malignancies in Children and Adults with Neurocutaneous Disorders.
Marjanska A, Jatczak-Gaca A, Wojtkiewicz A, Wysocki M, Styczynski J
Anticancer Res 2018 Sep;38(9):5453-5457. doi: 10.21873/anticanres.12877. PMID: 30194202
Lung Cancer and Multiple Neoplasms: A Retrospective Analysis.
Romaszko A, Świetlik E, Doboszyńska A, Szpruch P, Luks J
Adv Exp Med Biol 2016;911:53-8. doi: 10.1007/5584_2016_224. PMID: 26987325

Clinical prediction guides

Spinal Metastasis in Multiple Primary Malignancies Involving Lung Cancer: Clinical Characteristics and Survival.
Truong VT, Al-Shakfa F, Newman N, Roberge D, Masucci GL, Tran TPY, Boubez G, Shedid D, Yuh SJ, Wang Z
World Neurosurg 2022 Nov;167:e726-e731. Epub 2022 Aug 24 doi: 10.1016/j.wneu.2022.08.084. PMID: 36030008
Prognostic Value of Soluble Programmed Cell Death Ligand-1 (sPD-L1) in Various Cancers: A Meta-analysis.
Li X, Zheng Y, Yue F
Target Oncol 2021 Jan;16(1):13-26. doi: 10.1007/s11523-020-00763-5. PMID: 33222017
CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors.
Chen Y, Huang Y, Gao X, Li Y, Lin J, Chen L, Chang L, Chen G, Guan Y, Pan LK, Xia X, Guo Z, Pan J, Xu Y, Yi X, Chen C
Front Immunol 2020;11:1620. Epub 2020 Aug 10 doi: 10.3389/fimmu.2020.01620. PMID: 32903763Free PMC Article
Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.
Wang J, Zhang K, Wang J, Wu X, Liu X, Li B, Zhu Y, Yu Y, Cheng Q, Hu Z, Guo C, Hu S, Mu B, Tsai CH, Li J, Smith L, Yang L, Liu Q, Chu P, Chang V, Zhang B, Wu M, Jiang X, Yen Y
Oncotarget 2015 Aug 7;6(22):18905-20. doi: 10.18632/oncotarget.4305. PMID: 26056085Free PMC Article
Distribution and colocalization of markers for proliferation, invasion, motility and neoangiogenesis in benign melanocytic naevi and malignant melanomas.
Fröhlich E, Mack AF, Garbe C, Klessen C
Br J Dermatol 2005 Dec;153(6):1159-65. doi: 10.1111/j.1365-2133.2005.06883.x. PMID: 16307652

Recent systematic reviews

Detection of lymph node metastases by gadolinium-enhanced magnetic resonance imaging: systematic review and meta-analysis.
Klerkx WM, Bax L, Veldhuis WB, Heintz AP, Mali WP, Peeters PH, Moons KG
J Natl Cancer Inst 2010 Feb 24;102(4):244-53. Epub 2010 Feb 1 doi: 10.1093/jnci/djp514. PMID: 20124189

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